Monday, 27 May 2013

CVDs, statins and diabetes

a fish or a pill?
In a number of inhibition (on how we can stop/inhibit) and regression (on how we can reduce the extent or cure from) studies on CVDs, we have identified polar lipids of olive (present in olive oil and olive pomace) and fish origin.

In these in vivo studies, different groups of animals have been fed with either atherogenic diet (AD) (rabbit food supplemented with cholesterol) or AD enriched with the studied food components. We have found that olive polar lipids and fish polar lipids can inhibit the formation of atheromatic lesions. Olive pomace polar lipids (OPPL) can also cause regression of the formed atheromatic plaques, i.e. rendering the lesions thinner and thus decreasing the risk of CVDs. These beneficial activities of OPPL have been found similar to those of symvastatin.

This is the scientific evidence behind the "design" and production of a new aquacultured sea bream, as reported here.

Very recent evidence suggests though that "compared with pravastatin, treatment with higher potency statins, especially atorvastatin and simvastatin, might be associated with an increased risk of new onset diabetes" (Figure).

Adjusted survival curves for incident diabetes among new users of statins

A different approach could thus be proposed in order to lower risk from CVDs: Polar lipids of olive origin could be used in the treatment of CVDs instead of prescribing statins (with their side-effects on diabetes).

At the end of the day, an olive-pomace fed sea bream is more tasty than a statin pill !

Further reading
Carter A A et al. BMJ 2013;346:bmj.f2610
Karantonis HC, et al. Nutr Metab Cardiovasc Dis, 2006; 16 (3), 174-185.
Karantonis HC, et al. J Food Biochem, 2008; 32 (4), 443-459.
Nasopoulou C et al. Food Chem, 2010; 120 (3), 831-836.
Tsantila N, et al. Nutr Metab Cardiovasc Dis, 2010; 20 (10),740-747 .

No comments: